Michael Grunstein - Biography

Michael Grunstein (born 1946 in Romania) is a Distinguished Professor of Biological Chemistry at the Geffen School of Medicine at UCLA.

He obtained his Bachelor of Science degree from McGill University in Montreal, and his PhD from the University of Edinburgh, Scotland. He did his post-doctoral training at Stanford University in Palo Alto, California, where he invented the colony hybridization screening technique for recombinant DNAs in David Hogness' laboratory.

Soon after coming to UCLA in 1975, Grunstein pioneered the genetic analysis of histones in yeast and showed for the first time that histones are regulators of gene activity in living cells. His studies were among the most influential to counter the prevailing belief in the 1980s that eukaryotic genes, like previously studied bacterial genes, were predominantly subjected to transcriptional activation. His laboratory's studies provided inspiration for the eukaryotic histone code and underlie the modern study of epigenetics.

He received the Massry Prize in 2003 (with Roger Kornberg and David Allis). In April 2008, Grunstein was elected into the National Academy of Sciences.

See also

• List of members of the National Academy of sciences